Vomiting Larry battles "Ferrari of the virus world"

Paramedics dressed in protective attire walk in front of the ship, the Bellriva, in Wiesbaden December 8, 2012. The Bellriva has been quarantined after at least 30 passengers were found to be suffering from diarrhoea and vomiting. Authorities believed it is caused by the Norovirus, a virus that is spread from person-to-person and causes flu-like symptoms.

Credit: Reuters/Lisi Niesner

By Kate Kelland, Health and Science Correspondent

LONDON | Mon Dec 31, 2012 8:53am EST

LONDON (Reuters) - Poor Larry isn't looking too good. He's pale and clammy and he's been projectile vomiting over and over again while his carers just stand by and watch.

Yet their lack of concern for Larry is made up for by their intense interest in how far splashes of his vomit can fly, and how effectively they evade attempts to clean them up.

Larry is a "humanoid simulated vomiting system" designed to help scientists analyze contagion. And like millions around the world right now, he's struggling with norovirus - a disease one British expert describes as "the Ferrari of the virus world".

"Norovirus is one of the most infectious viruses of man," said Ian Goodfellow, a professor of virology at the department of pathology at Britain's University of Cambridge, who has been studying noroviruses for 10 years.

"It takes fewer than 20 virus particles to infect someone. So each droplet of vomit or gram of feces from an infected person can contain enough virus to infect more than 100,000 people."

Norovirus is hitting hard this year - and earlier too.

In Britain so far this season, more than a million people are thought to have suffered the violent vomiting and diarrhea it can bring. The Health Protection Agency (HPA) said this high rate of infection relatively early in the winter mirrors trends seen in Japan and Europe.

"In Australia the norovirus season also peaks during the winter, but this season it has gone on longer than usual and they are seeing cases into their summer," it said in a statement.

In the United States, the Centers for Disease Control and Prevention (CDC) say norovirus causes 21 million illnesses annually. Of those who get the virus, some 70,000 require hospitalization and around 800 die each year.

PROFUSE AND PROJECTILE

Norovirus dates back more than 40 years and takes its name from the U.S. city of Norwalk, Ohio, where there was an outbreak of acute gastroenteritis in school children in November 1968.

Symptoms include a sudden onset of vomiting, which can be projectile, and diarrhea, which may be profuse and watery. Some victims also suffer fevers, headaches and stomach cramps.

John Harris, an expert on the virus at Britain's HPA, puts it simply: "Norovirus is very contagious and very unpleasant."

What makes this such a formidable enemy is its ability to evade death from cleaning and to survive long periods outside a human host. Scientists have found norovirus can remain alive and well for 12 hours on hard surfaces and up to 12 days on contaminated fabrics such as carpets and upholstery. In still water, it can survive for months, maybe even years.

At the Health and Safety Laboratory in Derbyshire, northern England, where researcher Catherine Makison developed the humanoid simulated vomiting system and nicknamed him "Vomiting Larry", scientists analyzing his reach found that small droplets of sick can spread over three meters.

"The dramatic nature of the vomiting episodes produces a lot of aerosolized vomit, much of which is invisible to the naked eye," Goodfellow told Reuters.

Larry's projections were easy to spot because he had been primed with a "vomitus substitute", scientists explain, which included a fluorescent marker to help distinguish even small splashes - but they would not be at all easily visible under standard white hospital lighting.

Add the fact that norovirus is particularly resistant to normal household disinfectants and even alcohol hand gels, and it's little wonder the sickness wreaks such havoc in hospitals, schools, nursing homes, cruise ships and hotels.

During the two weeks up to December 23, there were 70 hospital outbreaks of norovirus reported in Britain, and last week a cruise ship that sails between New York and Britain's Southampton docked in the Caribbean with about 200 people on board suffering suspected norovirus.

MOVING TARGET

The good news, for some, is that not everyone appears to be equally susceptible to norovirus infection. According to Goodfellow, around 20 percent of Europeans have a mutation in a gene called FUT2 that makes them resistant.

For the rest the only likely good news will have to wait for the results of trials of a potential norovirus vaccine developed by U.S. drugmaker LigoCyte Pharmaceuticals Inc, or from one of several research teams around the world working on possible new antiviral drugs to treat the infection.

Early tests in 2011 indicated that around half of people vaccinated with the experimental shot, now owned by Japan's Takeda Pharmaceutical Co, were protected from symptomatic norovirus infection.

The bad news, virologists say, is that the virus changes constantly, making it a moving target for drug developers. There is also evidence that humans' immune response to infection is short-lived, so people can become re-infected by the same virus within just a year or two.

"There are many strains, and the virus changes very rapidly - it undergoes something virologists call genetic drift," Harris said in a telephone interview. "When it makes copies of itself, it makes mistakes in those copies - so each time you encounter the virus you may be encountering a slightly different one."

This means that even if a vaccine were to be fully developed - still a big 'if' - it would probably need to be tweaked and repeated in a slightly different formula each year to prevent people getting sick.

Until any effective drugs or vaccines are developed, experts reckon that like the common cold, norovirus will be an unwelcome guest for many winters to come. Their advice is to stay away from anyone with the virus, and use soap and water liberally.

"One of the reasons norovirus spreads so fast is that the majority of people don't wash their hands for long enough," said Goodfellow. "We'd suggest people count to 15 while washing their hands and ensure their hands are dried completely."

(Reporting by Kate Kelland; Editing by Will Waterman)

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International crew of three reaches orbiting space station

The Soyuz TMA-07M spacecraft carrying the International Space Station (ISS) crew of U.S. astronaut Thomas Marshburn, Russian cosmonaut Roman Romanenko and Canadian astronaut Chris Hadfield blasts off from its launch pad at the Baikonur cosmodrome December 19, 2012.

Credit: Reuters/Shamil Zhumatov

By Irene Klotz

CAPE CANAVERAL, Florida | Fri Dec 21, 2012 3:42pm EST

CAPE CANAVERAL, Florida (Reuters) - A Russian Soyuz capsule carrying a multinational crew of three arrived at the International Space Station on Friday, setting the stage for a Canadian for the first time to take command of the orbital research base.

The spacecraft carrying Chris Hadfield from the Canadian Space Agency, NASA's Tom Marshburn and Russian cosmonaut Roman Romanenko blasted off from Kazakhstan's Baikonur Cosmodrome on Wednesday and parked at the station's Rassvet docking module at 9:09 a.m. EST as the ships sailed 255 miles above northern Kazakhstan.

"The Soyuz sleigh has pulled into port at the International Space Station with a holiday gift of three new crewmembers," said NASA mission commentator Rob Navias.

The trio joined station commander Kevin Ford and Russian cosmonauts Oleg Novitskiy and Evgeni Tarelkin, who are two months into a planned six-month mission.

Ford is due to turn over command of the $100 billion research complex, a project of 15 nations, in mid-March to Hadfield, who will become the first Canadian to lead a space expedition.

"This is a big event for me personally," Hadfield said in a preflight interview. "It takes a lot of work, a lot of focus. It's something that I can look back on as an accomplishment and a threshold of my life."

Command of the station, which has been continuously occupied since November 2000, typically rotates between an American and a Russian crewmember.

In 2009, Belgian astronaut Frank De Winne broke that cycle to become the first European Space Agency commander. Japan's Koichi Wakata is training to lead the Expedition 39 crew in March 2014.

All three of the station's new residents have made previous spaceflights. Hadfield, 53, is a veteran of two space shuttle missions. Marshburn, 52, has one previous shuttle mission and Roman Romanenko, 41, a second-generation cosmonaut, served as a flight engineer aboard the space station in 2009.

The station crew will have some time off to celebrate several winter holidays in orbit - Christmas, the New Year and then Orthodox Christmas - before tackling a list of about 150 science experiments and station maintenance, including two spacewalks.

Among the studies will be medical research into how the human cardiovascular system changes in microgravity.

"When you live in an environment like that, the heart actually shrinks. Your blood vessel response changes. It actually sets us up to cardiovascular problems," Hadfield said. "We have a sequence of experiments that's taking blood samples and monitoring our body while we're exercising and doing different things to try and understand what's going on with our cardiovascular system," he said.

The research is expected to help doctors unravel the aging process on Earth, which is similar in many respects to what happens to the human body in weightlessness.

In addition to medical research, the space station serves as a laboratory for fluid physics and other microgravity sciences, a platform for several astronomical observatories and a testbed for robotics and other technologies.

(Edited by David Adams and Leslie Gevirtz)

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Approaching comet may outshine the moon

By Irene Klotz

Fri Dec 28, 2012 5:29pm EST

n">(Reuters) - A comet blazing toward Earth could outshine the full moon when it passes by at the end of next year - if it survives its close encounter with the sun.

The recently discovered object, known as comet ISON, is due to fly within 1.2 million miles (1.9 million km) from the center of the sun on November 28, 2013 said astronomer Donald Yeomans, head of NASA's Near Earth Object Program at the Jet Propulsion Laboratory in Pasadena, Calif.

As the comet approaches, heat from the sun will vaporize ices in its body, creating what could be a spectacular tail that is visible in Earth's night sky without telescopes or even binoculars from about October 2013 through January 2014.

If the comet survives, that is.

Comet ISON could break apart as it nears the sun, or it could fail to produce a tail of ice particles visible from Earth.

Celestial visitors like Comet ISON hail from the Oort Cloud, a cluster of frozen rocks and ices that circle the sun about 50,000 times farther away than Earth's orbit. Every so often, one will be gravitationally bumped out from the cloud and begin a long solo orbit around the sun.

On September 21, two amateur astronomers from Russia spotted what appeared to be a comet in images taken by a 16-inch (0.4-meter) telescope that is part of the worldwide International Scientific Optical Network, or ISON, from which the object draws its name.

"The object was slow and had a unique movement. But we could not be certain that it was a comet because the scale of our images are quite small and the object was very compact," astronomer Artyom Novichonok, one of the discoverers, wrote in a comets email list hosted by Yahoo.

Novichonok and co-discoverer Vitali Nevski followed up the next night with a bigger telescope at the Maidanak Observatory in Uzbekistan. Other astronomers did likewise, confirming the object, located beyond Jupiter's orbit in the constellation Cancer, was indeed a comet.

"It's really rare, exciting," Novichonok wrote.

Comet ISON's path is very similar to a comet that passed by Earth in 1680, one which was so bright its tail reportedly could be seen in daylight.

The projected orbit of comet ISON is so similar to the 1680 comet that some scientists are wondering if they are fragments from a common parent body.

"Comet ISON…could be the brightest comet seen in many generations - brighter even than the full moon," wrote British astronomer David Whitehouse in The Independent.

In 2013, Earth has two shots at a comet show. Comet Pan-STARRS is due to pass by the planet in March, eight months before ISON's arrival.

NASA's Mars Curiosity rover may be able to provide a preview.

Comet ISON is due to pass by the red planet in September and could be a target for the rover from its vantage point inside Gale Crater.

The last comet to dazzle Earth's night-time skies was Comet Hale-Bopp, which visited in 1997. Comet 17P/Holmes made a brief appearance in 2007.

(Editing by Kevin Gray and Leslie Gevirtz)

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Long-lived bats offer clues on diseases, aging

By Tan Ee Lyn

HONG KONG | Fri Dec 21, 2012 5:17am EST

HONG KONG (Reuters) - The bat, a reservoir for viruses like Ebola, SARS and Nipah, has for decades stumped scientists trying to figure out how it is immune to many deadly bugs but a recent study into its genes may finally shed some light, scientists said on Friday.

Studying the DNA of two distant bat species, the scientists discovered how genes dealing with the bats' immune system had undergone the most rapid change.

This may explain why they are relatively free of disease and live exceptionally long lives compared with other mammals of similar size, such as the rat, said Professor Lin-Fa Wang, an infectious disease expert at the Duke-NUS Graduate Medical School in Singapore who led the multi-centre study.

"We are not saying bats never get sick or never get infections. What we are saying is they handle infections a lot better," Wang said in a telephone interview.

What was missing from both species of bats was a gene segment known to trigger extreme, and potentially fatal, immune reactions to infections, called the cytokine storm.

Cytokine storms end up killing not only offending viruses in the body, but the host's own cells and tissues too.

"Viruses rarely kill the host. The killing comes from the host's immune response. So it looks like what bats are doing is depress the inflammation (cytokine storm). If we can learn that, we can design drugs to minimize the inflammation damage and control viral infection," Wang said.

The study, which saw the participation of researchers from China, Denmark, Australia and the United States, was published on Friday in the journal Science.

Compared with other mammals of similar size, bats live a long time, with lifespans of between 20 and 40 years. Rats live between 2 and 3 years, on average.

IMMUNE GENES LINKED TO FLIGHT

Interestingly, Wang and his colleagues found that the highly evolved genes that give bats their superior immune system also enable them to fly.

Out of more than 5,000 types of mammals on the planet, bats are the only one capable of sustained flight and some species can fly more than 1,000 km in a single night.

Such intense physical exertion is known to produce toxic "free radicals" that cause tissue damage and it is these same genes that give the bat the ability to repair itself, Wang said.

"What we found was the genes that evolved fastest were genes involved in repairing DNA damage. That makes sense ... because when you fly, metabolism goes up and it generates free radicals that are toxic to cells," Wang said.

"Because bats fly, they (would have had) to evolve and adapt ... to get genes that can repair DNA damage."

Wang said we have much to learn from the bat, which has evolved to avoid disease and live exceptionally long lives.

"Cancer, ageing and infectious disease, these are the three major areas of concern for people," he said.

"We have studied rats for 150 years to understand how to do better in these three areas. Now we have a system, the bat, that has done very well in evolution. We can learn from the bat. With modern techniques, we can design new drugs to slow down the ageing process, treat cancer, fight infections."

(Editing by Robert Birsel)

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NASA posts YouTube video debunking Maya "Armageddon"

A family of Osprey are seen outside the NASA Kennedy Space Center Vehicle Assembly Building (VAB) in Cape Canaveral, Florida on Thursday May 13, 2010.

Credit: Reuters/Bill Ingalls/NASA/Handout

By Irene Klotz

CAPE CANAVERAL, Florida | Fri Dec 21, 2012 2:12am EST

CAPE CANAVERAL, Florida (Reuters) - NASA is so sure there will be a December 22, 2012, it has already posted a YouTube video titled "Why the World Didn't End Yesterday."

Scientists say rumors on social media and the Internet of Earth's premature demise have been prompted by a misunderstanding of the ancient Maya calendar, which runs through December 21, 2012.

"It's just the end of the cycle and the beginning of the new one. It's just like on December 31, our calendar comes to an end, but a new calendar for the next year begins on January 1," Don Yeomans, head of NASA's Near-Earth Object program at the Jet Propulsion Laboratory in Pasadena, Calif., said in a separate YouTube video.

According to the story circulating on the Internet, an enormous rogue planet called Niburu is on a collision course with Earth.

"If it were, we would have seen it long ago and it if were invisible somehow, we would have seen its effects on the neighboring planets. Thousands of astronomers who scan the night skies on a daily basis have not seen this," Yeomans said.

Still, thousands of mystics and New Age dreamers have descended on ancient Maya temples across Mexico and Central America hoping to witness the birth of a new era when the day dubbed "end of the world" dawns on Friday.

So is NASA covering up to prevent panic?

"Can you imagine thousands of astronomers keeping the same secret from the public for several years?" Yeomans said.

Initially, Niburu, also known as Planet X, was to impact in May 2003, but when that didn't happen the doomsday date was moved to coincide with the end of one of the cycles of the ancient calendar at winter solstice -- December 21, 2012.

Other celestial events that will not be happening: a planetary alignment causing a massive tidal surge or a total blackout of Earth; a reversal in Earth's rotation; an impact by a giant asteroid; a giant solar storm.

"Since the beginning of recorded time, there have been literally hundreds of thousands of predictions for the end of the world," Yeomans said. "We're still here."

(Editing by Kevin Gray and M.D. Golan)

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Scientists in Hong Kong map initial anti-ageing formula

By Tan Ee Lyn

HONG KONG | Thu Dec 20, 2012 3:52am EST

HONG KONG (Reuters) - Scientists in Hong Kong appear to have mapped out a formula that can delay the ageing process in mice, a discovery they hope to replicate in people.

Their finding, published in the December issue of Cell Metabolism, builds on their work in 2005 which shed light on premature ageing, or progeria, a rare genetic disease that affects one in four million babies.

Progeria is obvious in the appearance of a child before it is a year old. Although their mental faculties are normal, they stop growing, lose body fat and suffer from wrinkled skin and hair loss. Like old people, they suffer stiff joints and a buildup of plaque in arteries which can lead to heart disease and stroke. Most die before they are 20 years old.

In that research, the team at the University of Hong Kong found that a mutation in the Lamin A protein, which lines the nucleus in human cells, disrupted the repair process in cells, thus resulting in accelerated aging.

Conversely, in their latest work using both mice and experiments in petri dishes, they found that normal and healthy Lamin A binds to and activates the gene SIRT1, which experts have long associated with longevity.

"We can develop drugs that mimic Lamin A or increase the binding between Lamin A and SIRT1," Liu Baohua, research assistant professor of biochemistry at the University of Hong Kong, told a news conference on Thursday.

The team went further to see if the binding efficiency between Lamin A and SIRTI would be boosted with resveratrol, a compound found in the skin of red grapes and other fruits which has been touted by some scientists and companies as a way to slow aging or remain healthy as people get older.

Associate professor Zhou Zhongjun, who led the study, said healthy mice fed with concentrated resveratrol fared significantly better than healthy mice not given the compound.

"We actually delayed the onset of ageing and extended the healthy lifespan," Zhou said of the mice.

Mice with progeria lived 30 percent longer when fed with resveratrol compared with progerial mice not given the compound.

Asked if their study supported the notion that drinking red wine delays ageing and reduces the risk of heart disease, Zhou said the alcohol content in wine would cause harm before any benefit could be derived.

"The amount of resveratrol in red wine is very low and it may not be beneficial. But the alcohol will cause damage to the body," Zhou said.

(Reporting by Tan Ee Lyn; Editing by Robert Birsel)

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Three-nation crew blasts off for space station

1 of 19. The Soyuz TMA-07M spacecraft carrying the International Space Station (ISS) crew of U.S. astronaut Thomas Marshburn, Russian cosmonaut Roman Romanenko and Canadian astronaut Chris Hadfield blasts off from its launch pad at the Baikonur cosmodrome December 19, 2012.

Credit: Reuters/Shamil Zhumatov

ALMATY | Wed Dec 19, 2012 12:24pm EST

ALMATY (Reuters) - A Soyuz spacecraft carrying a Russian, an American and a Canadian blasted off on Wednesday to the International Space Station (ISS), where the men are to spend half a year in orbit.

The Russian-built Soyuz TMA-07M lifted off on time, at 1212 GMT, from Russia's Baikonur cosmodrome in Kazakhstan.

On the crew's two-day trip to the ISS, Canadian Chris Hadfield is joined by U.S. astronaut Tom Mashburn and Russian cosmonaut Roman Romanenko.

They will join U.S. astronaut Kevin Ford and Russians Oleg Novitsky and Yevgeny Tarelkin, who have been manning the $100-billion, 15-nation research complex since October.

(Reporting by Dmitry Solovyov; Editing by Alison Williams)

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